stake有股份，赌注的意思，这个短语的意思就是愿意为了某事赌上一切。

to defend an action, opinion, or belief despite the risks that are involved为(行为、观点或信仰)甘冒风险;为…不惜赴汤蹈火

She was prepared to go to the stake for her views.她准备不惜一切代价维护自己的观点。