For reasons of economy and pollution, solvent-free methods are of great interest in order to
modernize classical procedures making them more clean, safe and easy to perform. Reactions
on solid mineral supports, reactions without any solvent/support or catalyst, and solid-liquid
phasetransfercatalysiscanbethusemployedwithnoticeableincreasesinreactivityand
selectivity. A comprehensive review of these techniques is presented here. These methodolo-
gies can moreover be improved to take advantage of microwave activation as a beneficial alter-
native to conventional heating under safe and efficient conditions with large enhancements in
yields and savings in time. |
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